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Acute stress occurs for short periods ranging from minutes to hours, while chronic stress persists for days, weeks, and even months

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Proinflammatory cytokines, TNF-α and IL-1β, as well as ROS, have been implicated in the disruption of BBB integrity, marked by downregulation of TJ proteins, occludin, claudin-5, and ZO-1 (Nishioku et al., 2010